Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:1225500 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
122703012281181089putative regulatory prophage proteinQuickGO ontologyBLASTP
12281151228870756putative prophage DNA primaseQuickGO ontologyBLASTP
12298021230689888DNA-binding prophage proteinQuickGO ontologyBLASTP
123188612335561671hypothetical proteinBLASTP
123360712346951089hypothetical proteinBLASTP
123477412359731200putative prophage integraseQuickGO ontologyBLASTP
12361971236706510transposaseQuickGO ontologyBLASTP
12372901237784495SsrA-binding proteinQuickGO ontologyBLASTP
12379331238367435hypothetical proteinBLASTP
12387941239135342hypothetical proteinBLASTP
123924912409101662DNA repair protein RecNQuickGO ontologyBLASTP
12409971241878882inorganic polyphosphateATP-NAD kinaseQuickGO ontologyBLASTP
12420021242580579heat shock protein GrpEQuickGO ontologyBLASTP
124268812439681281citrate synthaseQuickGO ontologyBLASTP
12450611245408348succinate dehydrogenase cytochrome b556 small membrane subunitQuickGO ontologyBLASTP
124540912471751767succinate dehydrogenase catalytic subunitQuickGO ontologyBLASTP
12472251247941717succinate dehydrogenase catalytic subunitQuickGO ontologyBLASTP
1248297125110428082-oxoglutarate dehydrogenase E1 componentQuickGO ontologyBLASTP