Pre_GI Gene

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Host: NC_017066 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017066:312000 Rickettsia typhi str. TH1527 chromosome, complete genome

Host Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. R. prowazekii, and genomic comparisons demonstrate colinearity and similarity to the genome of that organism except for two independent inversions near the origin and terminus. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3122583143092052ribonuclease EQuickGO ontologyBLASTP
316035316946912ribosomal large subunit pseudouridine synthase CQuickGO ontologyBLASTP
3170953182761182penicillin binding protein 4QuickGO ontologyBLASTP
318285319070786exodeoxyribonuclease IIIQuickGO ontologyBLASTP
319162320142981pyruvate dehydrogenase e1 component subunit alphaQuickGO ontologyBLASTP
320313321293981pyruvate dehydrogenase subunit betaQuickGO ontologyBLASTP
3217763235931818GTP-binding proteinQuickGO ontologyBLASTP
324435324941507hypothetical proteinBLASTP
3250503265011452isocitrate dehydrogenaseQuickGO ontologyBLASTP
326598326918321putative monovalent cationH antiporter subunit GQuickGO ontologyBLASTP
3270183280641047putative monovalent cationH antiporter subunit BQuickGO ontologyBLASTP
328057328704648heme exporter protein BQuickGO ontologyBLASTP
328772329230459hypothetical proteinBLASTP
329247329780534ubiquinol-cytochrome c reductase iron-sulfur subunitQuickGO ontologyBLASTP
3297873309831197cytochrome bQuickGO ontologyBLASTP
331438332193756cytochrome c1 heme proteinQuickGO ontologyBLASTP
332700333191492small heat shock proteinQuickGO ontologyBLASTP
333493334353861peptide chain release factor 2QuickGO ontologyBLASTP