Pre_GI Gene

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Host: NC_017066 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017066:243913 Rickettsia typhi str. TH1527 chromosome, complete genome

Host Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. R. prowazekii, and genomic comparisons demonstrate colinearity and similarity to the genome of that organism except for two independent inversions near the origin and terminus. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
243913244494582ribonuclease HIIQuickGO ontologyBLASTP
2445592465471989excinuclease ABC subunit BQuickGO ontologyBLASTP
246624246938315glutaredoxin 3QuickGO ontologyBLASTP
2470332488111779ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
2500782527952718DNA gyrase subunit AQuickGO ontologyBLASTP
254069254596528peptide deformylaseQuickGO ontologyBLASTP
254593255504912methionyl-tRNA formyltransferaseQuickGO ontologyBLASTP
255725255865141hypothetical proteinBLASTP
2595172605901074ATPaseQuickGO ontologyBLASTP
2612242623511128S-adenosylmethionine--tRNA ribosyltransferase-isomeraseQuickGO ontologyBLASTP