Pre_GI Gene

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Host: NC_017063 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017063:800156 Helicobacter pylori ELS37 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
800156800599444cag island proteinQuickGO ontologyBLASTP
8005928020371446cag pathogenicity island protein DeltaQuickGO ontologyBLASTP
802047802556510cag pathogenicity island protein cag4QuickGO ontologyBLASTP
802895803020126hypothetical protein
8030308052762247CAG pathogenicity island protein 5QuickGO ontologyBLASTP
805285806277993cag island protein DNA transfer proteinQuickGO ontologyBLASTP
806282806881600cag pathogenicity island protein cag6QuickGO ontologyBLASTP
8070168125865571cag pathogenicity island protein cag7QuickGO ontologyBLASTP
8126018141661566cag pathogenicity island protein XQuickGO ontologyBLASTP
8142198158261608cag island proteinQuickGO ontologyBLASTP
815831816589759cag pathogenicity island protein VQuickGO ontologyBLASTP
816985817641657cag island proteinQuickGO ontologyBLASTP
817677818519843CAG pathogenicity island protein TQuickGO ontologyBLASTP
818719819318600CAG pathogenicity island protein SQuickGO ontologyBLASTP
820059820238180hypothetical proteinBLASTP
8213228224521131cag pathogenicity island protein MQuickGO ontologyBLASTP
822467823387921cag pathogenicity island protein cagN cag17QuickGO ontologyBLASTP
823468824181714cag pathogenicity island protein LQuickGO ontologyBLASTP
8241788253231146cag pathogenicity island protein IQuickGO ontologyBLASTP
8253348264461113cag pathogenicity island protein HQuickGO ontology
826462826890429cag pathogenicity island protein GQuickGO ontology