Pre_GI Gene

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Host: NC_017063 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017063:775337 Helicobacter pylori ELS37 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
775337776158822hypothetical proteinBLASTP
777132777815684RNA methyltransferaseQuickGO ontologyBLASTP
777831778691861putative methylaseQuickGO ontologyBLASTP
77871677891920450S ribosomal protein L31QuickGO ontologyBLASTP
7791847805001317transcription termination factor RhoQuickGO ontologyBLASTP
780539781306768glutamate racemaseQuickGO ontologyBLASTP
781366781656291hypothetical proteinBLASTP
781923782033111hypothetical proteinBLASTP
7820387855833546cag pathogenicity island protein cag26QuickGO ontologyBLASTP
785969786157189hypothetical proteinBLASTP
7864377882481812regulator of nonsense transcripts 1QuickGO ontologyBLASTP
788299788457159hypothetical proteinBLASTP
788472788720249hypothetical protein
788722789003282hypothetical proteinBLASTP
789011789256246hypothetical protein
789253789927675hypothetical proteinBLASTP
790112791104993hypothetical proteinBLASTP
791101792006906GTPase EraQuickGO ontologyBLASTP
7920067933281323ATP-dependent protease ATP-binding subunit HslUQuickGO ontologyBLASTP
793337793879543ATP-dependent protease subunit HslVQuickGO ontologyBLASTP
79388379433245050S ribosomal protein L9QuickGO ontologyBLASTP
7943957965452151hypothetical proteinBLASTP
7966827981271446glutamine synthetaseQuickGO ontologyBLASTP