Pre_GI Gene

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Host: NC_017026 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017026:829444 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
829444829656213hypothetical protein
829704830201498MarR family transcriptional regulatorQuickGO ontologyBLASTP
830559831107549hypothetical proteinBLASTP
831352832158807hypothetical proteinBLASTP
832555832800246hypothetical proteinBLASTP
833031833345315transposaseQuickGO ontologyBLASTP
833487834005519PE-PGRS family proteinQuickGO ontologyBLASTP
834383834940558hypothetical proteinBLASTP
834937835443507transcriptional regulatorQuickGO ontologyBLASTP
8355578357031473-hydroxyisobutyrate dehydrogenaseQuickGO ontologyBLASTP
835652836179528hypothetical proteinBLASTP
838949839707759PE-PGRS family proteinQuickGO ontology
841443841700258hypothetical proteinBLASTP
841724842152429hypothetical proteinBLASTP
842233842370138hypothetical proteinBLASTP
842529842774246hypothetical proteinBLASTP
8428438436648223-hydroxyisobutyrate dehydrogenaseQuickGO ontologyBLASTP
8437398449111173putative acyl-CoA dehydrogenase FADE9QuickGO ontologyBLASTP
8449188464501533methylmalonate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
848605849483879PPE family proteinQuickGO ontologyBLASTP
8494948505491056PPE family proteinQuickGO ontologyBLASTP
850851851036186hypothetical proteinBLASTP