Pre_GI Gene

Some Help

Host: NC_017026 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017026:3894000 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
38943933894731339hypothetical protein
38947483895722975acyl-CoA synthetaseQuickGO ontologyBLASTP
38970793897669591hypothetical protein
38976693898178510hypothetical protein
390044639021281683PE-PGRS family proteinQuickGO ontologyBLASTP
39026233903342720hypothetical protein
390333939047991461hypothetical protein
39047623905415654hypothetical protein
39054693905609141hypothetical protein
39056403906044405hypothetical protein
39077593908595837hypothetical proteinBLASTP
390907039103891320PE-PGRS family proteinQuickGO ontologyBLASTP
39102933910970678hypothetical protein
391096739120401074hypothetical protein
39120033912938936hypothetical protein
39128753913369495hypothetical protein
39140243914299276hypothetical protein
39144283915084657fatty-acid-CoA ligaseQuickGO ontologyBLASTP
391513039161881059PE-PGRS family proteinQuickGO ontologyBLASTP