Pre_GI Gene

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Host: NC_017026 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017026:3754000 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
375418337555231341hypothetical proteinBLASTP
375556537567401176Trehalose-phosphate phosphataseQuickGO ontologyBLASTP
37567943756898105hypothetical proteinBLASTP
37569923757618627enoyl-CoA hydrataseQuickGO ontologyBLASTP
37576193757867249enoyl-CoA hydrataseQuickGO ontologyBLASTP
375787237592991428amidaseQuickGO ontologyBLASTP
37594083760061654putative HAD superfamily hydrolaseQuickGO ontologyBLASTP
376010037616051506cyclaseQuickGO ontologyBLASTP
37616103762500891hypothetical proteinBLASTP
3762509376411916111-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
37641483764342195hypothetical protein
37643523765236885transposase IS6110QuickGO ontologyBLASTP
37652873765613327putative transposaseQuickGO ontologyBLASTP
37657003766689990LYTB-related protein LYTB1QuickGO ontologyBLASTP
37666893767645957polyprenyl synthetaseQuickGO ontologyBLASTP
37684993768891393hypothetical proteinBLASTP
37688913769199309hypothetical proteinBLASTP
37693483770052705transposaseQuickGO ontologyBLASTP
37699793770812834transposaseQuickGO ontologyBLASTP
37709103771389480PE-PGRS family proteinQuickGO ontologyBLASTP
37716963772400705hypothetical protein
37723433773104762hypothetical protein
37731753774047873dehydrogenaseQuickGO ontologyBLASTP
37741213774831711hypothetical proteinBLASTP
377487837768301953short chain dehydrogenaseQuickGO ontologyBLASTP