Pre_GI Gene

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Host: NC_017026 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017026:3466809 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34658933466819927mechanosensitive ion channel protein MscSQuickGO ontologyBLASTP
346680934679241116peptide chain release factor 2QuickGO ontologyBLASTP
346805034694201371NADPHadrenodoxin oxidoreductase fprAQuickGO ontologyBLASTP
347169334727721080molybdopterin cofactor biosynthesis protein AQuickGO ontologyBLASTP
34728233473218396pterin-4-alpha-carbinolamine dehydrataseQuickGO ontologyBLASTP
34732153473727513molybdenum cofactor biosynthesis protein MoaCQuickGO ontologyBLASTP
34737443473995252molybdenum cofactor biosynthesis protein DQuickGO ontologyBLASTP
34744763474787312HAD family hydrolaseQuickGO ontologyBLASTP
34748043475334531hypothetical proteinBLASTP
347682534779941170molybdenum cofactor biosynthesis protein BQuickGO ontologyBLASTP
34780233478856834thiosulfate sulfurtransferaseQuickGO ontologyBLASTP
34788583479160303hypothetical proteinBLASTP
34791813479624444molybdenum cofactor biosynthesis protein EQuickGO ontologyBLASTP
34796213480223603hypothetical proteinBLASTP
348055834817601203cytochrome P450 141 cyp141QuickGO ontologyBLASTP
34823613482615255hypothetical proteinBLASTP
34826743483120447hypothetical proteinBLASTP
34832263483366141hypothetical proteinBLASTP
34837863484433648transcriptional regulatorQuickGO ontologyBLASTP
348453434857091176PPE family proteinQuickGO ontologyBLASTP
34858663486180315hypothetical proteinBLASTP
348620534872391035hypothetical proteinBLASTP
34872263487504279hypothetical proteinBLASTP