Pre_GI Gene

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Host: NC_017026 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017026:2786000 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2786176278627196hypothetical proteinBLASTP
278634927876141266putative carboxylesterase LIPQQuickGO ontologyBLASTP
27881402788748609enoyl-CoA hydrataseQuickGO ontologyBLASTP
278892927910132085hypothetical proteinBLASTP
27999562800147192hypothetical proteinBLASTP
28002982800921624hypothetical proteinBLASTP
28009112801663753hypothetical proteinBLASTP
28017162801937222hypothetical proteinBLASTP
28019432802368426hypothetical proteinBLASTP
280239128035721182branched-chain alpha-keto acid dehydrogenase subunit E2QuickGO ontologyBLASTP
280356928046151047putative pyruvate dehydrogenase E1 component subunit beta PDHBQuickGO ontologyBLASTP
280462628057291104putative pyruvate dehydrogenase E1 componentQuickGO ontologyBLASTP
28059922806813822putative citrate PRO-3S-lyase subunit betaQuickGO ontologyBLASTP
28068102807271462oxidase regulatory-related proteinQuickGO ontologyBLASTP
280736528085521188putative acyl-CoA dehydrogenase FADE19 MMGCQuickGO ontologyBLASTP