Pre_GI Gene

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Host: NC_017026 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017026:1686500 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
16872811687583303hypothetical proteinBLASTP
16875801687897318hypothetical proteinBLASTP
16903191690936618methyltransferaseQuickGO ontologyBLASTP
16911501691362213hypothetical proteinBLASTP
16914231691821399hypothetical proteinBLASTP
169186616928941029putative glycosyltransferaseQuickGO ontologyBLASTP
16929061693727822hypothetical proteinBLASTP
16939401694839900hypothetical proteinBLASTP
16950131695279267hypothetical proteinBLASTP
16955641696127564TDP-4-oxo-6-deoxy-D-glucose transaminaseQuickGO ontologyBLASTP
16963001696965666hypothetical proteinBLASTP
16969621697480519hypothetical proteinBLASTP
16977491698444696hypothetical proteinBLASTP
169924817006781431hypothetical proteinBLASTP
17008901701252363hypothetical proteinBLASTP
170235717036281272hypothetical proteinBLASTP
170410917051311023GDP-mannose 46-dehydrataseQuickGO ontologyBLASTP
17051281706096969nucleotide-sugar epimeraseQuickGO ontologyBLASTP
17060931706824732hypothetical proteinBLASTP
17068421707573732hypothetical proteinBLASTP
17076661708520855hypothetical proteinBLASTP
17085651709551987putative sugar transferaseQuickGO ontologyBLASTP
17100011710672672hypothetical proteinBLASTP