Pre_GI Gene

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Host: NC_017026 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017026:1095753 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
109575310971291377PE-PGRS family proteinQuickGO ontologyBLASTP
10975001098186687persistence regulator MprAQuickGO ontologyBLASTP
10981861098617432putative two component sensor kinase MPRBQuickGO ontologyBLASTP
109853810997671230two component system sensor kinase mprBQuickGO ontologyBLASTP
109974611011401395putative serine proteaseQuickGO ontologyBLASTP
11011401101685546molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
11017051102160456large-conductance mechanosensitive channelQuickGO ontologyBLASTP
11024831103229747adhesion component transport ATP-binding protein ABC transporterQuickGO ontologyBLASTP
11034511104254804adhesion component transport transmembrane proteinQuickGO ontologyBLASTP
110428311057911509hypothetical proteinBLASTP
11062311106734504hypothetical proteinBLASTP
11070921108069978polyprenyl synthetaseQuickGO ontologyBLASTP
11081301108786657hypothetical proteinBLASTP
11088591109191333hypothetical proteinBLASTP
110926511098585945-formyltetrahydrofolate cyclo-ligaseQuickGO ontologyBLASTP
11099591110879921putative UTP--glucose-1-phosphate uridylyltransferase GALUQuickGO ontologyBLASTP
11123011112912612putative ribosomal-protein-alanine acetyltransferase RIMJQuickGO ontologyBLASTP
111307311141491077transmembrane proteinQuickGO ontologyBLASTP
11145501114801252hypothetical proteinBLASTP
11148621115071210methyltransferaseQuickGO ontologyBLASTP
11150751115467393methyltransferaseQuickGO ontologyBLASTP
111543711164381002hypothetical proteinBLASTP
11164561117214759hypothetical proteinBLASTP
11172201117837618hypothetical proteinBLASTP