Pre_GI Gene

Some Help

Host: NC_016915 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016915:346000 Rickettsia rickettsii str. Hlp#2 chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3463363484082073ribonuclease EQuickGO ontologyBLASTP
3486473496601014heme O monooxygenaseQuickGO ontologyBLASTP
349673350584912ribosomal large subunit pseudouridine synthase CQuickGO ontologyBLASTP
351904352719816exodeoxyribonuclease IIIQuickGO ontologyBLASTP
352742353722981pyruvate dehydrogenase e1 component subunit alphaQuickGO ontologyBLASTP
353883354863981pyruvate dehydrogenase subunit betaQuickGO ontologyBLASTP
3550013568301830GTP-binding proteinQuickGO ontologyBLASTP
356972357178207hypothetical protein
357572357715144hypothetical proteinBLASTP
357935358489555Outer membrane proteinQuickGO ontologyBLASTP
3586663601171452isocitrate dehydrogenaseQuickGO ontologyBLASTP
360232360552321putative monovalent cationH antiporter subunit GQuickGO ontologyBLASTP
3606163616891074putative monovalent cationH antiporter subunit BQuickGO ontologyBLASTP
361682362329648heme exporter protein BQuickGO ontologyBLASTP
362404362859456hypothetical proteinBLASTP
362881363414534ubiquinol-cytochrome c reductase iron-sulfur subunitQuickGO ontologyBLASTP
3634213646171197cytochrome bQuickGO ontologyBLASTP
36492736500175hypothetical protein
365118365873756cytochrome c1 heme proteinQuickGO ontologyBLASTP
366433366603171hypothetical protein
366664367167504small heat shock proteinQuickGO ontologyBLASTP
367417367602186hypothetical protein
368033368320288hypothetical proteinBLASTP