Pre_GI Gene

Some Help

Host: NC_016915 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016915:278000 Rickettsia rickettsii str. Hlp#2 chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2780922808092718DNA gyrase subunit AQuickGO ontologyBLASTP
281629282135507transporterQuickGO ontologyBLASTP
282180282470291hypothetical proteinBLASTP
282591282710120hypothetical proteinBLASTP
282832283017186hypothetical proteinBLASTP
283044283196153hypothetical proteinBLASTP
283153283260108hypothetical proteinBLASTP
283468283995528peptide deformylaseQuickGO ontologyBLASTP
283992284903912methionyl-tRNA formyltransferaseQuickGO ontologyBLASTP
285120285566447hypothetical proteinBLASTP
2900732911251053ATPaseQuickGO ontologyBLASTP
291101291244144hypothetical proteinBLASTP
2913402924371098S-adenosylmethionine--tRNA ribosyltransferase-isomeraseQuickGO ontologyBLASTP
292604293032429hypothetical proteinBLASTP
2937272954961770multidrug ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
295678295950273hypothetical proteinBLASTP
2960992974691371cyanide-insensitive cytochrome bd-type quinol oxidase subunit IQuickGO ontologyBLASTP
2974772984961020cytochrome d ubiquinol oxidase subunit IIQuickGO ontologyBLASTP
298698298940243protein RelBQuickGO ontologyBLASTP
298951299211261protein RelEQuickGO ontologyBLASTP
299204300052849beta 14 glucosyltransferaseQuickGO ontologyBLASTP
3001293013671239peptidase M16 family proteinQuickGO ontologyBLASTP
301521302231711phosphoribosylaminoimidazolesuccinocarboxamide synthaseQuickGO ontologyBLASTP
3024483040341587hypothetical proteinBLASTP
3041313060381908threonyl-tRNA synthetaseQuickGO ontologyBLASTP
306495306638144hypothetical proteinBLASTP
306724306837114hypothetical proteinBLASTP
306912307142231ABC transporter ATPaseQuickGO ontologyBLASTP
307197307361165multidrug resistance ABC transporter ATP-binding proteinpermeaseQuickGO ontologyBLASTP
308024308173150hypothetical proteinBLASTP
308391308807417hypothetical proteinBLASTP
308807309451645hypothetical proteinBLASTP
30944430954299hypothetical proteinBLASTP
309736309888153hypothetical proteinBLASTP
3101973115581362outer membrane protein tolCQuickGO ontologyBLASTP
311560311958399hypothetical proteinBLASTP
311967312185219hypothetical proteinBLASTP
3121753138961722hypothetical proteinBLASTP
3141063160941989DNA topoisomerase IV subunit BQuickGO ontologyBLASTP