Pre_GI Gene

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Host: NC_016915 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016915:162841 Rickettsia rickettsii str. Hlp#2 chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
162168162860693tRNArRNA methyltransferaseQuickGO ontologyBLASTP
162841163026186hypothetical proteinBLASTP
1634711645171047putative nucleoside-diphosphate-sugar epimeraseQuickGO ontologyBLASTP
164514165473960Mrp proteinQuickGO ontologyBLASTP
1655801666201041protease activity modulatorQuickGO ontologyBLASTP
166713167573861protease activity modulatorQuickGO ontologyBLASTP
1676081691341527endopeptidaseQuickGO ontologyBLASTP
169296170039744hypothetical proteinBLASTP
170206170580375succinate dehydrogenase cytochrome b-556 subunitQuickGO ontologyBLASTP
170725171102378succinate dehydrogenase hydrophobic membrane anchor proteinQuickGO ontologyBLASTP
1712361730261791succinate dehydrogenase flavoprotein subunitQuickGO ontologyBLASTP
173173173829657hypothetical proteinBLASTP
17398917437839030S ribosomal protein S12QuickGO ontologyBLASTP
17440517488748330S ribosomal protein S7QuickGO ontologyBLASTP
1749001769992100elongation factor GQuickGO ontologyBLASTP
17714717722276tRNA-TrpQuickGO ontology
177421177621201preprotein translocase subunit SecEQuickGO ontologyBLASTP
177637178215579transcription antitermination protein NusGQuickGO ontologyBLASTP
17848517892243850S ribosomal protein L11QuickGO ontologyBLASTP
17892817964772050S ribosomal protein L1QuickGO ontologyBLASTP
17975818026751050S ribosomal protein L10QuickGO ontologyBLASTP
18046218084538450S ribosomal protein L7L12QuickGO ontologyBLASTP
1817911859124122DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP