Pre_GI Gene

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Host: NC_016915 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016915:13927 Rickettsia rickettsii str. Hlp#2 chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1392714850924hypothetical proteinBLASTP
1493515090156hypothetical proteinBLASTP
1509815625528ATPGTP hydrolaseQuickGO ontologyBLASTP
1561316317705zincmanganese ABC transporter substrate binding proteinQuickGO ontologyBLASTP
16563178731311polyA polymeraseQuickGO ontologyBLASTP
1836418549186hypothetical proteinBLASTP
1867419402729DNA translocation competence proteinQuickGO ontologyBLASTP
1942319671249hypothetical proteinBLASTP
20299258335535cell surface antigenQuickGO ontologyBLASTP
2611526219105hypothetical proteinBLASTP
2658226707126hypothetical proteinBLASTP
2715227892741hypothetical proteinBLASTP
2785928092234hypothetical proteinBLASTP
2823328415183hypothetical proteinBLASTP
2874729241495F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2924129714474F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2973329957225F0F1 ATP synthase subunit CQuickGO ontologyBLASTP
3015330881729F0F1 ATP synthase subunit AQuickGO ontologyBLASTP
3088631149264hypothetical proteinBLASTP
3126032093834protein-disulfide isomeraseQuickGO ontologyBLASTP
3225732778522transcriptional regulatorQuickGO ontologyBLASTP
33025346291605methyltransferaseQuickGO ontologyBLASTP
3475634965210hypothetical proteinBLASTP
35062361441083recombination protein FQuickGO ontologyBLASTP