Pre_GI Gene

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Host: NC_016914 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016914:99184 Rickettsia rickettsii str. Hino chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
991841000058227-cyano-7-deazaguanine reductaseQuickGO ontologyBLASTP
100322100882561putative cytoplasmic proteinQuickGO ontologyBLASTP
1009371023341398NADp transhydrogenase subunit betaQuickGO ontologyBLASTP
102473103207735OmpW family outer-membrane proteinQuickGO ontologyBLASTP
103362104246885transporter drugmetabolite exporter family proteinQuickGO ontologyBLASTP
1042331054891257MFS superfamily transporterQuickGO ontologyBLASTP
105486105662177hypothetical proteinBLASTP
105770105970201hypothetical proteinBLASTP
106324106626303preprotein translocase subunit SecGQuickGO ontologyBLASTP
1075331130915559hypothetical proteinBLASTP
1133881147671380cysteinyl-tRNA synthetaseQuickGO ontologyBLASTP
11500811589588830S ribosomal protein S2QuickGO ontologyBLASTP
116094117023930elongation factor TsQuickGO ontologyBLASTP
117497117886390hypothetical proteinBLASTP
118256118384129hypothetical proteinBLASTP
11853311992713953-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
119924120580657hypothetical proteinBLASTP
1207311219361206aspartate aminotransferaseQuickGO ontologyBLASTP