Pre_GI Gene

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Host: NC_016914 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016914:563941 Rickettsia rickettsii str. Hino chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
563941564270330acriflavin resistance plasma membrane proteinQuickGO ontologyBLASTP
565836566012177acriflavin resistance periplasmic proteinQuickGO ontologyBLASTP
5673905684091020glycosyltransferaseQuickGO ontologyBLASTP
568413568700288hypothetical proteinBLASTP
568729568971243hypothetical proteinBLASTP
569138569299162hypothetical proteinBLASTP
569388570200813diaminopimelate epimeraseQuickGO ontologyBLASTP
5701755714401266tRNA 2-methylthioadenosine synthase-like proteinQuickGO ontologyBLASTP
5716835727321050phenylalanyl-tRNA synthetase subunit alphaQuickGO ontologyBLASTP
5727295751852457phenylalanyl-tRNA synthetase subunit betaQuickGO ontologyBLASTP
5751905763291140DNA polymerase III subunit betaQuickGO ontologyBLASTP
576335576457123DnaJ family molecular chaperoneQuickGO ontologyBLASTP
576423576527105DnaJ family molecular chaperoneQuickGO ontologyBLASTP
576684577187504hypothetical proteinBLASTP
5773165798232508leucyl-tRNA synthetaseQuickGO ontologyBLASTP
580900581511612ribonuclease DQuickGO ontologyBLASTP
581660581965306septum formation initiatorQuickGO ontologyBLASTP
581962582654693phosphatidate cytidylyltransferaseQuickGO ontologyBLASTP
582614583294681undecaprenyl pyrophosphate synthetaseQuickGO ontologyBLASTP
5834675848971431osmolarity sensor protein EnvZQuickGO ontologyBLASTP
584881585561681transcriptional regulatorQuickGO ontologyBLASTP
585773586645873branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP