Pre_GI Gene

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Host: NC_016914 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016914:278500 Rickettsia rickettsii str. Hino chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2785502812672718DNA gyrase subunit AQuickGO ontologyBLASTP
281792282001210hypothetical protein
282088282330243transporterQuickGO ontologyBLASTP
282302282592291transporterQuickGO ontologyBLASTP
282637282921285hypothetical proteinBLASTP
283042283161120hypothetical proteinBLASTP
283283283468186hypothetical proteinBLASTP
283495283647153hypothetical proteinBLASTP
283604283711108hypothetical proteinBLASTP
283919284446528peptide deformylaseQuickGO ontologyBLASTP
284443285354912methionyl-tRNA formyltransferaseQuickGO ontologyBLASTP
289796290362567hypothetical proteinBLASTP
2905212915731053ATPaseQuickGO ontologyBLASTP
2917882928851098S-adenosylmethionine--tRNA ribosyltransferase-isomeraseQuickGO ontologyBLASTP
293052293480429hypothetical proteinBLASTP
293651293890240hypothetical proteinBLASTP
293974294108135hypothetical proteinBLASTP
2941762959451770multidrug ABC transporter ATP-binding proteinQuickGO ontologyBLASTP