Pre_GI Gene

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Host: NC_016914 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016914:13826 Rickettsia rickettsii str. Hino chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1382614749924hypothetical proteinBLASTP
1483514990156hypothetical proteinBLASTP
1499815525528ATPGTP hydrolaseQuickGO ontologyBLASTP
1551316217705zincmanganese ABC transporter substrate binding proteinQuickGO ontologyBLASTP
16463177731311polyA polymeraseQuickGO ontologyBLASTP
1826318469207hypothetical proteinBLASTP
1857219300729DNA translocation competence proteinQuickGO ontologyBLASTP
1932119467147hypothetical proteinBLASTP
1966519781117hypothetical proteinBLASTP
20187258745688cell surface antigenQuickGO ontologyBLASTP
2615626260105hypothetical proteinBLASTP
2662226747126hypothetical proteinBLASTP
2719227932741hypothetical proteinBLASTP
2789928132234hypothetical proteinBLASTP
2827328455183hypothetical proteinBLASTP
2878729281495F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2928129754474F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2977329997225F0F1 ATP synthase subunit CQuickGO ontologyBLASTP
3019330921729F0F1 ATP synthase subunit AQuickGO ontologyBLASTP
3092631189264hypothetical proteinBLASTP
3130032133834protein-disulfide isomeraseQuickGO ontologyBLASTP
3229732818522transcriptional regulatorQuickGO ontologyBLASTP
33065346691605methyltransferaseQuickGO ontologyBLASTP
3479235001210hypothetical proteinBLASTP
35098361801083recombination protein FQuickGO ontologyBLASTP