Pre_GI Gene

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Host: NC_016914 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016914:1136700 Rickettsia rickettsii str. Hino chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
113670011377191020NADHubiquinone oxidoreductase subunit HQuickGO ontologyBLASTP
113784111398562016NADH dehydrogenase subunit GQuickGO ontologyBLASTP
11398591140215357hypothetical proteinBLASTP
114038411430202637aconitate hydrataseQuickGO ontologyBLASTP
11432021143540339F0F1 ATP synthase subunit epsilonQuickGO ontologyBLASTP
114359811450191422F0F1 ATP synthase subunit betaQuickGO ontologyBLASTP
11451921146163972F0F1 ATP synthase subunit gammaQuickGO ontologyBLASTP
114629711478291533F0F1 ATP synthase subunit alphaQuickGO ontologyBLASTP
11479951148549555F0F1 ATP synthase subunit deltaQuickGO ontologyBLASTP
114871311500921380dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
11502471150675429ferroxidaseQuickGO ontologyBLASTP
11516341151750117hypothetical protein
11520091152311303beta-lactamase OXA-18QuickGO ontologyBLASTP
11524501152722273beta-lactamaseQuickGO ontologyBLASTP
115300111553732373multimodular transpeptidase-transglycosylase PBP 1AQuickGO ontologyBLASTP