Pre_GI Gene

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Host: NC_016911 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016911:563822 Rickettsia rickettsii str. Hauke chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
563822564151330acriflavin resistance plasma membrane proteinQuickGO ontologyBLASTP
565717565893177acriflavin resistance periplasmic proteinQuickGO ontologyBLASTP
5672715682901020glycosyltransferaseQuickGO ontologyBLASTP
568294568581288hypothetical proteinBLASTP
568610568852243hypothetical proteinBLASTP
569019569180162hypothetical proteinBLASTP
569269570081813diaminopimelate epimeraseQuickGO ontologyBLASTP
5700565713211266tRNA 2-methylthioadenosine synthase-like proteinQuickGO ontologyBLASTP
5715645726131050phenylalanyl-tRNA synthetase subunit alphaQuickGO ontologyBLASTP
5726105750662457phenylalanyl-tRNA synthetase subunit betaQuickGO ontologyBLASTP
5750715762101140DNA polymerase III subunit betaQuickGO ontologyBLASTP
576216576338123DnaJ family molecular chaperoneQuickGO ontologyBLASTP
576304576408105DnaJ family molecular chaperoneQuickGO ontologyBLASTP
576565577068504hypothetical proteinBLASTP
5771975797042508leucyl-tRNA synthetaseQuickGO ontologyBLASTP
580223580354132hypothetical proteinBLASTP
580781581392612ribonuclease DQuickGO ontologyBLASTP
581541581846306septum formation initiatorQuickGO ontologyBLASTP
581843582535693phosphatidate cytidylyltransferaseQuickGO ontologyBLASTP
582495583175681undecaprenyl pyrophosphate synthetaseQuickGO ontologyBLASTP
5833485847781431osmolarity sensor protein EnvZQuickGO ontologyBLASTP
584762585442681transcriptional regulatorQuickGO ontologyBLASTP
585654586526873branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP