Pre_GI Gene

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Host: NC_016911 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016911:278415 Rickettsia rickettsii str. Hauke chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2784152811322718DNA gyrase subunit AQuickGO ontologyBLASTP
281955282197243transporterQuickGO ontologyBLASTP
282169282459291transporterQuickGO ontologyBLASTP
282504282788285hypothetical proteinBLASTP
282909283028120hypothetical proteinBLASTP
283150283335186hypothetical proteinBLASTP
283362283514153hypothetical proteinBLASTP
283471283578108hypothetical proteinBLASTP
283786284313528peptide deformylaseQuickGO ontologyBLASTP
284310285221912methionyl-tRNA formyltransferaseQuickGO ontologyBLASTP
285438285881444hypothetical proteinBLASTP
289663290229567hypothetical proteinBLASTP
2903882914401053ATPaseQuickGO ontologyBLASTP
2916552927521098S-adenosylmethionine--tRNA ribosyltransferase-isomeraseQuickGO ontologyBLASTP
292919293347429hypothetical proteinBLASTP
293518293757240hypothetical proteinBLASTP
293841293975135hypothetical proteinBLASTP
2940432958121770multidrug ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
295992296264273hypothetical proteinBLASTP