Pre_GI Gene

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Host: NC_016911 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016911:13826 Rickettsia rickettsii str. Hauke chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1382614749924hypothetical proteinBLASTP
1483514990156hypothetical proteinBLASTP
1499815525528ATPGTP hydrolaseQuickGO ontologyBLASTP
1551316217705zincmanganese ABC transporter substrate binding proteinQuickGO ontologyBLASTP
16546177181173polyA polymeraseQuickGO ontologyBLASTP
1826218486225hypothetical proteinBLASTP
1857119299729DNA translocation competence proteinQuickGO ontologyBLASTP
1932019466147hypothetical proteinBLASTP
1966419780117hypothetical proteinBLASTP
20186257865601cell surface antigenQuickGO ontologyBLASTP
2606826172105hypothetical proteinBLASTP
2653426659126hypothetical proteinBLASTP
2710427844741hypothetical proteinBLASTP
2781128044234hypothetical proteinBLASTP
2818528367183hypothetical proteinBLASTP
2869929193495F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2919329666474F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2968529909225F0F1 ATP synthase subunit CQuickGO ontologyBLASTP
3010530833729F0F1 ATP synthase subunit AQuickGO ontologyBLASTP
3083831101264hypothetical proteinBLASTP
3121232045834protein-disulfide isomeraseQuickGO ontologyBLASTP
3220932730522transcriptional regulatorQuickGO ontologyBLASTP
32977345811605methyltransferaseQuickGO ontologyBLASTP
3470434913210hypothetical proteinBLASTP
35010360921083recombination protein FQuickGO ontologyBLASTP