Pre_GI Gene

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Host: NC_016911 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016911:1136584 Rickettsia rickettsii str. Hauke chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
113658411376031020NADHubiquinone oxidoreductase subunit HQuickGO ontologyBLASTP
113772511397402016NADH dehydrogenase subunit GQuickGO ontologyBLASTP
11397431140099357hypothetical proteinBLASTP
114026811429042637aconitate hydrataseQuickGO ontologyBLASTP
11430861143424339F0F1 ATP synthase subunit epsilonQuickGO ontologyBLASTP
114348211449031422F0F1 ATP synthase subunit betaQuickGO ontologyBLASTP
11450761146047972F0F1 ATP synthase subunit gammaQuickGO ontologyBLASTP
114618111477131533F0F1 ATP synthase subunit alphaQuickGO ontologyBLASTP
11478791148433555F0F1 ATP synthase subunit deltaQuickGO ontologyBLASTP
114859711499761380dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
11501311150559429ferroxidaseQuickGO ontologyBLASTP
11515181151634117hypothetical protein
11518931152195303beta-lactamase OXA-18QuickGO ontologyBLASTP
11523341152606273beta-lactamaseQuickGO ontologyBLASTP
115288511552572373multimodular transpeptidase-transglycosylase PBP 1AQuickGO ontologyBLASTP