Pre_GI Gene

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Host: NC_016908 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016908:563747 Rickettsia rickettsii str. Colombia chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
563747564076330acriflavin resistance plasma membrane proteinQuickGO ontologyBLASTP
564246564377132acriflavin resistance plasma membrane proteinQuickGO ontologyBLASTP
56451956461496RND family efflux transporterQuickGO ontologyBLASTP
565642565818177acriflavin resistance periplasmic proteinQuickGO ontologyBLASTP
5671965682151020glycosyltransferaseQuickGO ontologyBLASTP
568219568506288hypothetical proteinBLASTP
568535568777243hypothetical proteinBLASTP
568944569105162hypothetical proteinBLASTP
569194570006813diaminopimelate epimeraseQuickGO ontologyBLASTP
5699815712461266tRNA 2-methylthioadenosine synthase-like proteinQuickGO ontologyBLASTP
5714895725381050phenylalanyl-tRNA synthetase subunit alphaQuickGO ontologyBLASTP
5725355749912457phenylalanyl-tRNA synthetase subunit betaQuickGO ontologyBLASTP
5749965761351140DNA polymerase III subunit betaQuickGO ontologyBLASTP
576141576263123DnaJ family molecular chaperoneQuickGO ontologyBLASTP
576229576333105DnaJ family molecular chaperoneQuickGO ontologyBLASTP
576490576993504hypothetical proteinBLASTP
5771225796292508leucyl-tRNA synthetaseQuickGO ontologyBLASTP
580148580303156hypothetical proteinBLASTP
580707581318612ribonuclease DQuickGO ontologyBLASTP
581467581772306septum formation initiatorQuickGO ontologyBLASTP
581769582461693phosphatidate cytidylyltransferaseQuickGO ontologyBLASTP
582421583101681undecaprenyl pyrophosphate synthetaseQuickGO ontologyBLASTP
5832745847041431osmolarity sensor protein EnvZQuickGO ontologyBLASTP
584688585368681transcriptional regulatorQuickGO ontologyBLASTP
585580586452873branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP