Pre_GI Gene

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Host: NC_016908 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016908:278457 Rickettsia rickettsii str. Colombia chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2784572811742718DNA gyrase subunit AQuickGO ontologyBLASTP
281994282236243transporterQuickGO ontologyBLASTP
282208282498291transporterQuickGO ontologyBLASTP
282543282827285hypothetical proteinBLASTP
282948283067120hypothetical proteinBLASTP
283189283374186hypothetical proteinBLASTP
283401283553153hypothetical proteinBLASTP
283510283617108hypothetical proteinBLASTP
283825284352528peptide deformylaseQuickGO ontologyBLASTP
284349285260912methionyl-tRNA formyltransferaseQuickGO ontologyBLASTP
285477285920444hypothetical proteinBLASTP
289702290268567hypothetical proteinBLASTP
2904272914791053ATPaseQuickGO ontologyBLASTP
291455291598144hypothetical proteinBLASTP
2916942927911098S-adenosylmethionine--tRNA ribosyltransferase-isomeraseQuickGO ontologyBLASTP
292958293386429hypothetical proteinBLASTP
293557293796240hypothetical proteinBLASTP
293880294014135hypothetical proteinBLASTP
2940822958511770multidrug ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
296031296303273hypothetical proteinBLASTP
2964552978251371cyanide-insensitive cytochrome bd-type quinol oxidase subunit IQuickGO ontologyBLASTP
2978332988521020cytochrome d ubiquinol oxidase subunit IIQuickGO ontologyBLASTP
299054299296243protein RelBQuickGO ontologyBLASTP
299307299567261protein RelEQuickGO ontologyBLASTP
299560300408849beta 14 glucosyltransferaseQuickGO ontologyBLASTP