Pre_GI Gene

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Host: NC_016908 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016908:167423 Rickettsia rickettsii str. Colombia chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1674231689491527endopeptidaseQuickGO ontologyBLASTP
169103169846744hypothetical proteinBLASTP
170013170387375succinate dehydrogenase cytochrome b-556 subunitQuickGO ontologyBLASTP
170532170909378succinate dehydrogenase hydrophobic membrane anchor proteinQuickGO ontologyBLASTP
1710431728331791succinate dehydrogenase flavoprotein subunitQuickGO ontologyBLASTP
172980173636657hypothetical proteinBLASTP
17379517418439030S ribosomal protein S12QuickGO ontologyBLASTP
17421117469348330S ribosomal protein S7QuickGO ontologyBLASTP
1747061768052100elongation factor GQuickGO ontologyBLASTP
17694917702476tRNA-TrpQuickGO ontology
177223177423201preprotein translocase subunit SecEQuickGO ontologyBLASTP
177439178017579transcription antitermination protein NusGQuickGO ontologyBLASTP
17828717872443850S ribosomal protein L11QuickGO ontologyBLASTP
17873017944972050S ribosomal protein L1QuickGO ontologyBLASTP
17956018006951050S ribosomal protein L10QuickGO ontologyBLASTP
18026418064438150S ribosomal protein L7L12QuickGO ontologyBLASTP
1815911857124122DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP
1859701900884119DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP