Pre_GI Gene

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Host: NC_016908 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016908:13826 Rickettsia rickettsii str. Colombia chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1382614749924hypothetical proteinBLASTP
1483514990156hypothetical proteinBLASTP
1499815525528ATPGTP hydrolaseQuickGO ontologyBLASTP
1551316217705zincmanganese ABC transporter substrate binding proteinQuickGO ontologyBLASTP
16463177731311polyA polymeraseQuickGO ontologyBLASTP
1826318469207hypothetical proteinBLASTP
1857218706135hypothetical proteinBLASTP
1932119467147hypothetical proteinBLASTP
1966519781117hypothetical proteinBLASTP
20197257975601cell surface antigenQuickGO ontologyBLASTP
2607926183105hypothetical proteinBLASTP
2654526670126hypothetical proteinBLASTP
2711527855741hypothetical proteinBLASTP
2782228055234hypothetical proteinBLASTP
2819628378183hypothetical proteinBLASTP
2871029204495F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2920429677474F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2969629920225F0F1 ATP synthase subunit CQuickGO ontologyBLASTP
3011630844729F0F1 ATP synthase subunit AQuickGO ontologyBLASTP
3084931112264hypothetical proteinBLASTP
3122332056834protein-disulfide isomeraseQuickGO ontologyBLASTP
3222032741522transcriptional regulatorQuickGO ontologyBLASTP
32988345921605methyltransferaseQuickGO ontologyBLASTP
3471534924210hypothetical proteinBLASTP
35021361031083recombination protein FQuickGO ontologyBLASTP