Pre_GI Gene

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Host: NC_016908 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016908:100000 Rickettsia rickettsii str. Colombia chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
100269100829561putative cytoplasmic proteinQuickGO ontologyBLASTP
1008841022811398NADp transhydrogenase subunit betaQuickGO ontologyBLASTP
102420103154735OmpW family outer-membrane proteinQuickGO ontologyBLASTP
103309104193885transporter drugmetabolite exporter family proteinQuickGO ontologyBLASTP
1041801054361257MFS superfamily transporterQuickGO ontologyBLASTP
105433105609177hypothetical proteinBLASTP
105717105917201hypothetical proteinBLASTP
106271106573303preprotein translocase subunit SecGQuickGO ontologyBLASTP
1074611129775517hypothetical proteinBLASTP
1132751146541380cysteinyl-tRNA synthetaseQuickGO ontologyBLASTP
11489511578288830S ribosomal protein S2QuickGO ontologyBLASTP
115981116910930elongation factor TsQuickGO ontologyBLASTP
117384117773390hypothetical proteinBLASTP
117979118116138hypothetical proteinBLASTP
118143118271129hypothetical proteinBLASTP
11842011981413953-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
119811120467657hypothetical proteinBLASTP
1206181218231206aspartate aminotransferaseQuickGO ontologyBLASTP
12201712209478hypothetical proteinBLASTP