Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:4093000 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4093068409330423750S ribosomal protein L28QuickGO ontologyBLASTP
4093325409349216850S ribosomal protein L33QuickGO ontologyBLASTP
40935904094399810formamidopyrimidine5-formyluracil 5-hydroxymethyluracil DNA glycosylaseQuickGO ontologyBLASTP
40944384094917480phosphopantetheine adenylyltransferaseQuickGO ontologyBLASTP
4094925409620212783-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
409661540976731059lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
409767040987941125lipopolysaccharide core biosynthesis protein RfaGQuickGO ontologyBLASTP
40987874099584798lipopolysaccharide core heptoseI kinase RfaPQuickGO ontologyBLASTP
409960041006161017lipopolysaccharide 13-galactosyltransferaseQuickGO ontologyBLASTP
41006334101628996lipopolysaccharide 12-glucosyltransferaseQuickGO ontologyBLASTP
41016384102330693lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
410235641033811026UDP-galactosegalactosyl LPS alpha12-galactosyltransferaseQuickGO ontologyBLASTP
41034664104449984putative beta13-glucosyltransferaseQuickGO ontologyBLASTP
410449541057481254lipid A-core surface polymer ligaseQuickGO ontologyBLASTP
41058184106789972ADP-heptose--LPS heptosyltransferaseQuickGO ontologyBLASTP
410679341078391047ADP-heptose--LPS heptosyltransferaseQuickGO ontologyBLASTP
41078494108781933ADP-L-glycero-D-manno-heptose-6-epimeraseQuickGO ontologyBLASTP
4108995411019111972-amino-3-ketobutyrate coenzyme A ligaseQuickGO ontologyBLASTP
411020141112261026L-threonine 3-dehydrogenaseQuickGO ontologyBLASTP
41114654112367903putative glycosyl transferaseQuickGO ontologyBLASTP
41124384112941504IS1 ORF2QuickGO ontologyBLASTP
41128604113135276IS1 repressor protein InsAQuickGO ontologyBLASTP
41131964113336141putative glycosyl transferaseQuickGO ontologyBLASTP
41133234114282960putative polysaccharide deacetylaseQuickGO ontologyBLASTP
411428641155691284AmiB activatorQuickGO ontologyBLASTP
411557941171231545phosphoglyceromutaseQuickGO ontologyBLASTP