Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:3946500 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39467613947114354DNA-binding transcriptional repressor ArsRQuickGO ontologyBLASTP
394716839484571290arsenical pump membrane proteinQuickGO ontologyBLASTP
39484703948895426arsenate reductaseQuickGO ontologyBLASTP
39490293949325297hypothetical proteinBLASTP
39494323949710279permeaseQuickGO ontologyBLASTP
394979739509691173integrase for IS21 orfAQuickGO ontologyBLASTP
39509693951766798IS21 ORF2QuickGO ontologyBLASTP
39518963952567672hypothetical proteinBLASTP
39528303953132303IS600 ORF1QuickGO ontologyBLASTP
39532733953986714IS600 ORF2QuickGO ontologyBLASTP
39542223954587366IS2 repressor TnpAQuickGO ontologyBLASTP
39545453955450906IS2 transposase TnpBQuickGO ontologyBLASTP
39557523956597846hypothetical proteinBLASTP
39570563957559504IS1 ORF2QuickGO ontologyBLASTP
39574783957753276IS1 repressor protein InsAQuickGO ontologyBLASTP
39579993958565567outer membrane lipoproteinQuickGO ontologyBLASTP
39587213959251531putative DNA-binding transcriptional regulatorQuickGO ontologyBLASTP
39592933959940648putative Mg2 transport ATPaseQuickGO ontologyBLASTP
39600043960342339acid-resistance proteinQuickGO ontologyBLASTP
39604463960778333acid-resistance proteinQuickGO ontologyBLASTP
39610333961605573acid-resistance membrane proteinQuickGO ontologyBLASTP
39624043962931528DNA-binding transcriptional activatorQuickGO ontologyBLASTP
39632483963364117hypothetical protein
396327039644271158multidrug efflux system protein MdtEQuickGO ontologyBLASTP