Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:3923908 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
392390839250321125transporterQuickGO ontologyBLASTP
392503239277672736ribosome-associated ATPaseQuickGO ontologyBLASTP
392776439288311068hypothetical proteinBLASTP
392919739308191623hypothetical proteinBLASTP
393108139326881608hypothetical proteinBLASTP
393307239341241053hypothetical proteinBLASTP
393444039356421203hypothetical proteinBLASTP
393587439373731500phosphate transporterQuickGO ontologyBLASTP
39376173937952336universal stress protein UspBQuickGO ontologyBLASTP
39383433938777435universal stress global response regulator UspAQuickGO ontologyBLASTP
393909539405641470dipeptidetripeptide permease BQuickGO ontologyBLASTP
39406133941365753putative methyltransferaseQuickGO ontologyBLASTP
394137339434152043oligopeptidase AQuickGO ontologyBLASTP
39436183944460843putative DNA processing proteinQuickGO ontologyBLASTP
394453239458841353glutathione reductaseQuickGO ontologyBLASTP