Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:3485631 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
348563134871121482outer membrane channel proteinQuickGO ontologyBLASTP
34872603487931672hypothetical proteinBLASTP
348793734890971161synthetaseamidaseQuickGO ontologyBLASTP
34891353489923789LigB family dioxygenaseQuickGO ontologyBLASTP
34900663490839774zinc transporter ZupTQuickGO ontologyBLASTP
34908973491067171hypothetical proteinBLASTP
3491328349198165434-dihydroxy-2-butanone 4-phosphate synthaseQuickGO ontologyBLASTP
34923553492645291hypothetical proteinBLASTP
34929283493479552putative fimbrial proteinQuickGO ontologyBLASTP
349353934960432505putative outer membrane usher proteinQuickGO ontologyBLASTP
34960593496808750putative fimbrial chaperoneQuickGO ontologyBLASTP
349681034978741065hypothetical proteinBLASTP
349789434989251032IS630 orfQuickGO ontologyBLASTP
34990723499272201glycogen synthesis protein GlgSQuickGO ontologyBLASTP
34995413500170630oxidoreductaseQuickGO ontologyBLASTP
350019735018581662hypothetical proteinBLASTP
35019583502209252hypothetical proteinBLASTP
350265235040851434bifunctional heptose 7-phosphate kinaseheptose 1-phosphate adenyltransferaseQuickGO ontologyBLASTP
350413335069732841bifunctional glutamine-synthetase adenylyltransferasedeadenyltransferaseQuickGO ontologyBLASTP