Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:3282654 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
328265432839161263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
32840383284973936DNA-binding transcriptional regulator LysRQuickGO ontologyBLASTP
32849603285652693putative racemaseQuickGO ontologyBLASTP
328578332872011419sugar transporterQuickGO ontologyBLASTP
328751632882777622-deoxy-D-gluconate 3-dehydrogenaseQuickGO ontologyBLASTP
328834232891788375-keto-4-deoxyuronate isomeraseQuickGO ontologyBLASTP
328946532906461182putative acyltransferaseQuickGO ontologyBLASTP
329090132921301230transporter proteinQuickGO ontologyBLASTP
32925903293222633hypothetical proteinBLASTP
32938793294382504IS1 ORF2QuickGO ontologyBLASTP
32943013294576276IS1 repressor protein InsAQuickGO ontologyBLASTP
32948063295141336putative transcriptional regulatorQuickGO ontologyBLASTP
32951343295616483hypothetical proteinBLASTP
3295650329573081hypothetical proteinBLASTP
32958853296190306hypothetical proteinBLASTP
32966203297057438hypothetical proteinBLASTP
32973353297826492Tetratricopeptide TPR_3 repeat-containing proteinQuickGO ontologyBLASTP
32981613298619459transcriptional regulatorQuickGO ontologyBLASTP
329870132997321032IS630 orfQuickGO ontologyBLASTP
32998633300228366IS2 repressor TnpAQuickGO ontologyBLASTP
33001863301091906IS2 transposase TnpBQuickGO ontologyBLASTP
330092533023701446hypothetical proteinBLASTP