Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:2940000 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29401972940910714IS600 ORF2QuickGO ontologyBLASTP
29410512941353303IS600 orf1QuickGO ontologyBLASTP
29414052941602198hypothetical proteinBLASTP
294194929431241176ISCps8 transposaseQuickGO ontologyBLASTP
29434512943969519IS629 ORF2QuickGO ontologyBLASTP
29439812944334354IS629 orfQuickGO ontologyBLASTP
29443342944660327IS629 ORF1QuickGO ontologyBLASTP
29447582945018261hypothetical proteinBLASTP
29450152945605591hypothetical proteinBLASTP
29461012946298198Colicin-Ia immunity proteinQuickGO ontologyBLASTP
29480742948640567hypothetical proteinBLASTP
29489312949848918iron-regulated proteinQuickGO ontologyBLASTP
29498562950632777TonB-dependent colicin J protein CjrBQuickGO ontologyBLASTP
295080129530622262colicin Js-sensitive receptor proteinQuickGO ontologyBLASTP
295303229543061275putative enterotoxin protein SenBQuickGO ontologyBLASTP
29548322955233402transposaseQuickGO ontologyBLASTP
295533129567221392protein encoded within ISQuickGO ontologyBLASTP
295700529585401536transposaseQuickGO ontologyBLASTP
29585572959312756transposase subunitQuickGO ontologyBLASTP
29595632959910348protein encoded within ISQuickGO ontologyBLASTP
29599072960308402hypothetical proteinBLASTP
29604282960703276IS1 repressor protein InsAQuickGO ontologyBLASTP
29606222961125504IS1 ORF2QuickGO ontologyBLASTP
296141529625901176ISCps8 transposaseQuickGO ontologyBLASTP