Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:2678691 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
267869126800371347IS4 orfQuickGO ontologyBLASTP
268028226817151434sucrose hydrolaseQuickGO ontologyBLASTP
26817232682718996sucrose specific repressorQuickGO ontologyBLASTP
26829492683167219permease DsdXQuickGO ontologyBLASTP
268318526845131329D-serine dehydrataseQuickGO ontologyBLASTP
268462126861591539putative multidrug efflux system protein YQuickGO ontologyBLASTP
268615926873221164multidrug resistance protein KQuickGO ontologyBLASTP
26877382688352615DNA-binding transcriptional activator EvgAQuickGO ontologyBLASTP
268835726919503594hybrid sensory histidine kinase in two-component regulatory system with EvgAQuickGO ontologyBLASTP
269200626931511146putative CoA-transferaseQuickGO ontologyBLASTP
26932252694169945putative transporter YfdVQuickGO ontologyBLASTP
269423926959331695putative oxalyl-CoA decarboxylaseQuickGO ontologyBLASTP
269598726972371251formyl-coenzyme A transferaseQuickGO ontologyBLASTP
26977502698373624hypothetical proteinBLASTP
26988982699200303IS600 orf1QuickGO ontologyBLASTP
26993412700054714IS600 ORF2QuickGO ontologyBLASTP
27002892700531243hypothetical proteinBLASTP
27008842701804921lipid A biosynthesis palmitoleoyl acyltransferaseQuickGO ontologyBLASTP
270229627035341239aminotransferaseQuickGO ontologyBLASTP
270391127056081698signal transduction histidine kinase LytSQuickGO ontologyBLASTP
27056232706357735LytTR family two component transcriptional regulatorQuickGO ontologyBLASTP