Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:267758 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2667122677941083hypothetical proteinBLASTP
2677582696081851type VI secretion system protein ImpGQuickGO ontologyBLASTP
269612270025414type VI secretion system lysozyme-like proteinQuickGO ontologyBLASTP
270032270580549type VI secretion protein EvpBQuickGO ontologyBLASTP
270617271507891hypothetical proteinBLASTP
271558271782225hypothetical proteinBLASTP
271817272317501hypothetical proteinBLASTP
272744272887144hypothetical proteinBLASTP
273014273532519hemolysin co-regulated proteinQuickGO ontologyBLASTP
2737422753581617Rhs element proteinQuickGO ontologyBLASTP
2755732771081536transposaseQuickGO ontologyBLASTP
277125277880756transposase subunitQuickGO ontologyBLASTP
278042278527486hypothetical proteinBLASTP
2786032828204218rhs core protein with extensionQuickGO ontologyBLASTP
282832283281450hypothetical proteinBLASTP
283543283821279receptorQuickGO ontologyBLASTP
283822284679858receptor proteinQuickGO ontologyBLASTP
284840285553714hypothetical proteinBLASTP
285694285996303IS600 orf1QuickGO ontologyBLASTP
286077286394318Rhs family proteinQuickGO ontologyBLASTP
286394286771378hypothetical proteinBLASTP
2872402883761137receptorQuickGO ontologyBLASTP
288418289188771C-N hydrolase family amidaseQuickGO ontologyBLASTP
289342289815474C-lysozyme inhibitorQuickGO ontologyBLASTP