Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:246715 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
246715247470756hydroxyacylglutathione hydrolaseQuickGO ontologyBLASTP
247504248226723hypothetical proteinBLASTP
248223248690468ribonuclease HQuickGO ontologyBLASTP
248755249486732DNA polymerase III subunit epsilonQuickGO ontologyBLASTP
24961924969577tRNA-AspQuickGO ontologyBLASTP
250025250810786aminopeptidaseQuickGO ontologyBLASTP
250947251426480hypothetical proteinBLASTP
252419252901483type VI secretion system effectorQuickGO ontologyBLASTP
2529252542771353hypothetical proteinBLASTP
2578312592431413hypothetical proteinBLASTP
259248259991744type VI secretion-associated proteinQuickGO ontologyBLASTP
2599882627772790ATP-dependent Clp proteinase ATP-binding chainQuickGO ontologyBLASTP
262786263547762putative membrane protein Aec26QuickGO ontologyBLASTP
2635522648831332hypothetical proteinBLASTP
264886265410525lipoproteinQuickGO ontologyBLASTP
2654072666871281type VI secretion system protein ImpIQuickGO ontologyBLASTP