Pre_GI Gene

Some Help

Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:2341127 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
233985323411301278nucleoside permeaseQuickGO ontologyBLASTP
234112723421311005putative hydrolaseQuickGO ontologyBLASTP
23421282343093966kinaseQuickGO ontologyBLASTP
23430672343813747GntR family transcriptional regulatorQuickGO ontologyBLASTP
23438652344683819hypothetical proteinBLASTP
23447482345548801bifunctional hydroxy-methylpyrimidine kinase hydroxy-phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
23455452346333789hydroxyethylthiazole kinaseQuickGO ontologyBLASTP
23465562346828273transcriptional repressor RcnR to maintain nickel and cobalt homeostasisQuickGO ontologyBLASTP
23469492347773825nickelcobalt efflux protein RcnAQuickGO ontologyBLASTP
23479922348330339hypothetical proteinBLASTP
234841223494311020putative fimbrial-like adhesin protein StcDQuickGO ontologyBLASTP
234944723514502004fimbrial outer membrane usher proteinQuickGO ontologyBLASTP
23515322352035504IS1 ORF2QuickGO ontologyBLASTP
23519542352229276IS1 repressor protein InsAQuickGO ontologyBLASTP
23522582352695438fimbrial outer membrane usher proteinQuickGO ontologyBLASTP
23527202353394675pili assembly chaperoneQuickGO ontologyBLASTP
23534742354016543fimbrial protein domain-containing proteinQuickGO ontologyBLASTP
23543082354589282hypothetical proteinBLASTP
235483423559431110antiporter inner membrane proteinQuickGO ontologyBLASTP
235607523581082034methionyl-tRNA synthetaseQuickGO ontologyBLASTP
23582492359070822hypothetical proteinBLASTP
23590052359382378IS1 transposaseQuickGO ontologyBLASTP
23594272359702276IS1 repressor protein InsAQuickGO ontologyBLASTP
23597782360311534hypothetical proteinBLASTP
236043523619611527hypothetical proteinBLASTP
236195423630901137hypothetical proteinBLASTP
236308723650872001hypothetical proteinBLASTP