Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:1839739 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18397391840308570hypothetical proteinBLASTP
184031218405392284-oxalocrotonate tautomeraseQuickGO ontologyBLASTP
18406391841373735hypothetical proteinBLASTP
18413611841711351hypothetical proteinBLASTP
184191418430501137receptorQuickGO ontologyBLASTP
18434071843583177hypothetical protein
18436311844134504IS1 ORF2QuickGO ontologyBLASTP
18440531844328276IS1 repressor protein InsAQuickGO ontologyBLASTP
18445961845048453ISSfl2 ORFQuickGO ontologyBLASTP
18450651845820756transposase subunitQuickGO ontologyBLASTP
184583718473721536transposaseQuickGO ontologyBLASTP
18475681847852285ISSfl2 ORFQuickGO ontologyBLASTP
18480911848417327ISSfl2 ORFQuickGO ontologyBLASTP
18483521848855504IS1 ORFQuickGO ontologyBLASTP
18487741849049276IS1 repressor protein InsAQuickGO ontologyBLASTP
18492181849457240hypothetical protein
184943518536524218rhs core protein with extensionQuickGO ontologyBLASTP
18539101854905996H repeat-containing proteinQuickGO ontologyBLASTP
185540618588223417rhs core protein with extensionQuickGO ontologyBLASTP
185946918615772109Rhs element proteinQuickGO ontologyBLASTP