Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:1818897 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18188971819550654formate dehydrogenase-N subunit gammaQuickGO ontologyBLASTP
18195431820427885formate dehydrogenase nitrate-inducible iron-sulfur subunitQuickGO ontologyBLASTP
182044018228512412formate dehydrogenase-N subunit alpha nitrate-inducibleQuickGO ontologyBLASTP
18229001823487588formate dehydrogenase N subunit nitrate-inducible subunit alphaQuickGO ontologyBLASTP
18237191824600882aromatic amino acid exporterQuickGO ontologyBLASTP
182485918259591101outer membrane porin proteinQuickGO ontologyBLASTP
182612918272921164hypothetical proteinBLASTP
182737618284071032IS630 orfQuickGO ontologyBLASTP
18283881828522135glycoprotein with ribonuclease inhibitor domain yddK modular proteinQuickGO ontologyBLASTP
182953018309181389nitratenitrite transport protein NarUQuickGO ontologyBLASTP
183100018347403741cryptic nitrate reductase 2 subunit alphaQuickGO ontologyBLASTP
183473718362811545cryptic nitrate reductase 2 subunit betaQuickGO ontologyBLASTP
18362811836976696nitrate reductase 2 subunit deltaQuickGO ontologyBLASTP
18369731837653681cryptic nitrate reductase 2 subunit gammaQuickGO ontologyBLASTP
18377321838625894hypothetical proteinBLASTP
18387211839566846N-hydroxyarylamine O-acetyltransferaseQuickGO ontologyBLASTP