Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:1781644 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17816441782573930DNA replication terminus site-binding proteinQuickGO ontologyBLASTP
178257017839731404fumarate hydrataseQuickGO ontologyBLASTP
178412317854691347IS4 orfQuickGO ontologyBLASTP
178599617882752280putative oxidoreductaseQuickGO ontologyBLASTP
17885231788720198hypothetical proteinBLASTP
17887951789556762transcriptional regulator YdeOQuickGO ontologyBLASTP
178995717916391683sulfataseQuickGO ontologyBLASTP
179169117928481158hypothetical proteinBLASTP
179314517948301686ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
179486817972402373hypothetical proteinBLASTP
179728518000802796peptidaseQuickGO ontologyBLASTP
180044218018421401glutamate decarboxylaseQuickGO ontologyBLASTP
180199818035331536glutamateg-aminobutyrate antiporterQuickGO ontologyBLASTP