Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:15401 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1540115610210Hokgef cell toxic proteinQuickGO ontologyBLASTP
1624917094846transposaseQuickGO ontologyBLASTP
1714218125984integrase for IS21 orfAQuickGO ontologyBLASTP
1815918314156putative transposase protein IstAQuickGO ontologyBLASTP
1831419111798IS21 ORF2QuickGO ontologyBLASTP
1912119510390hypothetical proteinBLASTP
19793209591167pH-dependent sodiumproton antiporterQuickGO ontologyBLASTP
2101921924906transcriptional activator NhaRQuickGO ontologyBLASTP
2196222921960hypothetical proteinBLASTP
2293423737804hypothetical proteinBLASTP
2377924054276IS1 repressor protein InsAQuickGO ontologyBLASTP
2397324476504IS1 ORF2QuickGO ontologyBLASTP
2448724855369hypothetical proteinBLASTP
25296264171122hypothetical proteinBLASTP
272012746426430S ribosomal protein S20QuickGO ontologyBLASTP
2756727785219hypothetical proteinBLASTP
2779328734942bifunctional riboflavin kinaseFMN adenylyltransferaseQuickGO ontologyBLASTP
28777315932817isoleucyl-tRNA synthetaseQuickGO ontologyBLASTP
3159332087495lipoprotein signal peptidaseQuickGO ontologyBLASTP
3221232661450FKBP-type peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
32663336139514-hydroxy-3-methylbut-2-enyl diphosphate reductaseQuickGO ontologyBLASTP
3367934593915ribonucleoside hydrolase RihCQuickGO ontologyBLASTP
3476035581822dihydrodipicolinate reductaseQuickGO ontologyBLASTP
358243591996hypothetical proteinBLASTP
36037371851149carbamoyl phosphate synthase small subunitQuickGO ontologyBLASTP
37203404243222carbamoyl phosphate synthase large subunitQuickGO ontologyBLASTP