Pre_GI Gene

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Host: NC_016822 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016822:1339058 Shigella sonnei 53G, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13390581339843786high-affinity zinc transporter membrane proteinQuickGO ontologyBLASTP
13398401340595756high-affinity zinc transporter ATPaseQuickGO ontologyBLASTP
13406741341606933high-affinity zinc transporter periplasmic proteinQuickGO ontologyBLASTP
134162213429441323putative peptidaseQuickGO ontologyBLASTP
13430641344035972lipid A biosynthesis KDO2-lauroyl-lipid IVA acyltransferaseQuickGO ontologyBLASTP
134425513455051251hypothetical proteinBLASTP
13455961346099504IS1 ORFQuickGO ontologyBLASTP
13460181346293276IS1 repressor protein InsAQuickGO ontologyBLASTP
134801813498861869hypothetical proteinBLASTP
13499751350187213hypothetical proteinBLASTP
13503361350611276IS1 repressor protein InsAQuickGO ontologyBLASTP
13505301351033504IS1 ORF2QuickGO ontologyBLASTP
13511541351996843hypothetical proteinBLASTP
135205613534981443pyruvate kinaseQuickGO ontologyBLASTP
13536261354495870DNA-binding transcriptional regulator HexRQuickGO ontologyBLASTP
13545181354667150hypothetical proteinBLASTP
135483313563081476glucose-6-phosphate 1-dehydrogenaseQuickGO ontologyBLASTP
135654313583541812phosphogluconate dehydrataseQuickGO ontologyBLASTP
13583911359032642keto-hydroxyglutarate-aldolaseketo-deoxy- phosphogluconate aldolaseQuickGO ontologyBLASTP
135908813602661179phosphoribosylglycinamide formyltransferase 2QuickGO ontologyBLASTP
13604001360690291DNA damage-inducible protein YebGQuickGO ontologyBLASTP
13607571361113357hypothetical proteinBLASTP
13614401362099660hypothetical proteinBLASTP
136230813643682061protease 2QuickGO ontologyBLASTP
13643651365027663exodeoxyribonuclease XQuickGO ontologyBLASTP