Pre_GI Gene

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Host: NC_016811 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016811:2903871 Legionella pneumophila subsp. pneumophila ATCC 43290 chromosome,

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29038712904785915UDP-3-O-acyl-N-acetylglucosamine deacetylaseQuickGO ontologyBLASTP
290503329062291197cell division protein FtsZQuickGO ontologyBLASTP
290642429076861263cell division protein FtsAQuickGO ontologyBLASTP
29076622908381720cell division protein FtsQQuickGO ontologyBLASTP
290839729095031107D-alanine--D-alanine ligaseQuickGO ontologyBLASTP
29094752910413939UDP-N-acetylenolpyruvoylglucosamine reductaseQuickGO ontologyBLASTP
291041029118191410UDP-N-acetylmuramateL-alanine ligase MurCQuickGO ontologyBLASTP
291182929130131185cell division protein FtsWQuickGO ontologyBLASTP
291301029143531344UDP-N-muramoylalanine-D-glutamate ligaseQuickGO ontologyBLASTP
291436729154851119phospho-N-acetylmuramoyl-pentapeptide transferaseQuickGO ontologyBLASTP
291556729169521386UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligaseQuickGO ontologyBLASTP
29171452917924780cell division protein ZipAQuickGO ontologyBLASTP
291792929214233495chromosome segregation protein SMCQuickGO ontologyBLASTP
29215982922278681acid phosphatase class BQuickGO ontologyBLASTP
292238029234411062hypothetical proteinBLASTP
29237512924563813transmembrane proteinQuickGO ontologyBLASTP
29246382925120483transcription elongation factor GreAQuickGO ontologyBLASTP
292512929283323204carbamoyl phosphate synthase large subunitQuickGO ontologyBLASTP