Pre_GI Gene

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Host: NC_016768 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016768:830000 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
830211830708498transcriptional regulatorQuickGO ontologyBLASTP
831066831614549hypothetical proteinBLASTP
831859832665807hypothetical proteinBLASTP
832699833307609hypothetical proteinBLASTP
833538833852315transposaseQuickGO ontologyBLASTP
833994834512519hypothetical proteinBLASTP
834890835447558hypothetical proteinBLASTP
835444835950507transcriptional regulatorQuickGO ontologyBLASTP
836158836685528hypothetical proteinBLASTP
8367058390562352PE-PGRS family proteinQuickGO ontologyBLASTP
8394558420582604hypothetical proteinBLASTP
842149842406258hypothetical proteinBLASTP
842430842858429hypothetical proteinBLASTP
843211843480270hypothetical proteinBLASTP
8435498444338853-hydroxyisobutyrate dehydrogenase mmsBQuickGO ontologyBLASTP
8444448456161173acyl-CoA dehydrogenase fadE9QuickGO ontologyBLASTP
8456238471551533methylmalonate-semialdehyde dehydrogenase mmsAQuickGO ontologyBLASTP
8473618491151755PE-PGRS family proteinQuickGO ontologyBLASTP
8493058512451941hypothetical proteinBLASTP
851544851729186transposaseQuickGO ontologyBLASTP
851943852668726hypothetical proteinBLASTP