Pre_GI Gene

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Host: NC_016768 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016768:476500 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
476653476901249hypothetical proteinBLASTP
476938477579642secreted proteinQuickGO ontologyBLASTP
4775864788151230lipoprotein LpqKQuickGO ontologyBLASTP
4788254800121188acyl-CoA dehydrogenase fadE7QuickGO ontologyBLASTP
480048480419372hypothetical proteinBLASTP
4806144834902877transmembrane transporter mmpL1QuickGO ontologyBLASTP
483487483915429membrane protein mmpS1QuickGO ontologyBLASTP
4842364859931758fatty-acid-CoA ligase FadD30QuickGO ontologyBLASTP
4859904901984209membrane bound polyketide synthase pks6QuickGO ontologyBLASTP
490146490964819beta lactamase like proteinQuickGO ontologyBLASTP
4910424920521011F420-dependent glucose-6-phosphate dehydrogenase fgd1QuickGO ontologyBLASTP
4920454941172073phosphate acetyltransferase ptaQuickGO ontologyBLASTP
4941104952671158acetate kinase ackAQuickGO ontologyBLASTP
4953214975732253serinethreonine-protein kinase pknGQuickGO ontologyBLASTP
497573498559987glutamine-binding lipoprotein glnHQuickGO ontologyBLASTP
4985594998781320hypothetical proteinBLASTP