Pre_GI Gene

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Host: NC_016768 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016768:3774105 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
377410537774013297DNA polymerase subunit III alpha dnaE2QuickGO ontologyBLASTP
377753637788761341hypothetical proteinBLASTP
377891837800931176trehalose-6-phosphate phosphatase otsB2QuickGO ontologyBLASTP
37803303780971642enoyl-CoA hydratase echA18QuickGO ontologyBLASTP
37809723781220249enoyl-CoA hydratase echA18_1QuickGO ontologyBLASTP
378122537826521428amidase amiDQuickGO ontologyBLASTP
37827603783413654hypothetical proteinBLASTP
378345237849571506cyclaseQuickGO ontologyBLASTP
37849623785852891hypothetical proteinBLASTP
3785861378747116111-deoxy-D-xylulose 5-phosphate synthase dxs2QuickGO ontologyBLASTP
37876943788689996lytB-related protein lytB1QuickGO ontologyBLASTP
378868337897351053polyprenyl synthetase idsBQuickGO ontologyBLASTP
37904893790881393hypothetical proteinBLASTP
37908813791189309hypothetical proteinBLASTP
37913383792042705transposaseQuickGO ontologyBLASTP
37920323792709678transposaseQuickGO ontologyBLASTP
379289937950942196PE-PGRS family proteinQuickGO ontologyBLASTP
37951653796037873dehydrogenaseQuickGO ontologyBLASTP
37961113796821711lipoprotein LpqDQuickGO ontologyBLASTP
379686737988191953acyl-CoA reductase acrA1QuickGO ontologyBLASTP