Pre_GI Gene

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Host: NC_016768 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016768:3296478 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
32964783297089612ribosomal-protein-alanine acetyltransferase rimJQuickGO ontologyBLASTP
329715232984321281molybdopterin biosynthesis protein MoeA1QuickGO ontologyBLASTP
32985093299429921UTP-glucose-1-phosphate uridylyltransferase galUQuickGO ontologyBLASTP
32995303300123594hypothetical proteinBLASTP
33001763300529354hypothetical proteinBLASTP
33006023301258657hypothetical proteinBLASTP
33013193302296978polyprenyl-diphosphate synthase grcC2QuickGO ontologyBLASTP
330242533035851161hypothetical proteinBLASTP
330359233061592568adhesion component transport transmembrane proteinQuickGO ontologyBLASTP
33061523306898747adhesion component transport ATP-binding protein ABC transporterQuickGO ontologyBLASTP
33072213307676456large-conductance ion mechanosensitive channel mscLQuickGO ontologyBLASTP
33076963308241546pterin-4-alpha-carbinolamine dehydratase moaB2QuickGO ontologyBLASTP
330824133096351395serine protease pepDQuickGO ontologyBLASTP
330967933111931515two component system sensor kinase mprBQuickGO ontologyBLASTP
33111933311885693mycobacterial persistence regulator mprAQuickGO ontologyBLASTP
331220533136231419hypothetical proteinBLASTP
3313642331416652550S ribosomal protein L32 rpmFQuickGO ontologyBLASTP
331434533153521008PE-PGRS family proteinQuickGO ontologyBLASTP
331556933183702802hypothetical proteinBLASTP